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The three-dimensional structure of H-2Db at 2.4 Å resolution: Implications for antigen-determinant selection

Identifieur interne : 004306 ( Main/Exploration ); précédent : 004305; suivant : 004307

The three-dimensional structure of H-2Db at 2.4 Å resolution: Implications for antigen-determinant selection

Auteurs : Aideen C. M. Young [États-Unis] ; Weiguo Zhang [États-Unis] ; James C. Sacchettini [États-Unis] ; Stanley G. Nathenson [États-Unis]

Source :

RBID : ISTEX:40B671E64C83B8B133FCB623BF61CAEF12F74B78

English descriptors

Abstract

Abstract: Solution at 2.4 Å resolution of the structure of H-2Db with the influenza virus peptide NP366–374 (ASNEN-METM) and comparison with the H-2Kb-VSV (RGY-VYQGL) structure allow description of the molecular details of MHC class I peptide binding interactions for mice of the H-2b haplotype, revealing a strategy that maximizes the repertoire of peptides that can be presented. The H-2Db cleft has a mouse-specific hydrophobic ridge that causes a compensatory arch in the backbone of the peptide, exposing the arch residues to TCR contact and requiring the peptide to be at least 9 residues. This ridge occurs in about 40% of the known murine D and L allelic molecules, classifying them as a structural subgroup.

Url:
DOI: 10.1016/0092-8674(94)90171-6


Affiliations:


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Le document en format XML

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<div type="abstract" xml:lang="en">Abstract: Solution at 2.4 Å resolution of the structure of H-2Db with the influenza virus peptide NP366–374 (ASNEN-METM) and comparison with the H-2Kb-VSV (RGY-VYQGL) structure allow description of the molecular details of MHC class I peptide binding interactions for mice of the H-2b haplotype, revealing a strategy that maximizes the repertoire of peptides that can be presented. The H-2Db cleft has a mouse-specific hydrophobic ridge that causes a compensatory arch in the backbone of the peptide, exposing the arch residues to TCR contact and requiring the peptide to be at least 9 residues. This ridge occurs in about 40% of the known murine D and L allelic molecules, classifying them as a structural subgroup.</div>
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